Mucormycosis is any fungal infection caused by fungi in the order Mucorales Generally In the rhinocerebral form, the mortality rate is between 30% and 70%, whereas disseminated mucormycosis presents with the highest mortality rate. Mucormycosis is an invasive fungal infection caused by filamentous fungi of the Mucoraceae family. The genera most commonly responsible are Mucor or Rhizopus. The disease occurs mostly in association with diabetic ketoacidosis.‎Abstract · ‎INTRODUCTION · ‎CASE REPORT · ‎DISCUSSION. Mucormycosis is a rare fungal infection that affects immunocompromised patients, and the rhinoorbitocerebral presentation is the most common.


Author: Astrid Little Jr.
Country: Sri Lanka
Language: English
Genre: Education
Published: 4 May 2014
Pages: 362
PDF File Size: 37.79 Mb
ePub File Size: 8.96 Mb
ISBN: 353-2-12552-894-1
Downloads: 97454
Price: Free
Uploader: Astrid Little Jr.


Mucormycosis - Wikipedia

For all that has been exposed and given the rarity of the entity and the rhinocerebral mucormycosis of the manifestations, diagnosis in rhinocerebral mucormycosis is dependent on a high degree of suspicion; hence, the authors deem it appropriate to publish the case.

Histological examination of the biopsy tissue with culture is the gold standard.


In this case, the best surgical option was discussed with several specialists, with the final decision being conservative intervention with turbinectomy and drainage of rhinocerebral mucormycosis sinuses. The initial course was unfavourable, with progression of rhinocerebral mucormycosis infection to the cervical region, requiring surgical intervention.

There are a few poor prognostic factors described in the literature, including the delay in starting treatment in the six days after diagnosis, hemiparesis or hemiplegia and bilateral involvement of the sinuses, orbit and palate.

Some studies have linked diabetes to a more favourable prognosis.


So, rhinocerebral mucormycosis some studies show, this can be an option. Given the rarity and severity of mucormycosis, the authors publish this case as a reminder of this clinical entity, aiming rhinocerebral mucormycosis warn about the new therapeutic challenges, particularly with less radical surgery.

A successful treatment of rhinocerebral mucormycosis due to Rhizopus oryzae

Learning points Mucormycosis is a rare fungal infection, potentially fatal, that usually affects immunocompromised patients, and the rhino-orbito-cerebral presentation is the most common clinical form of the disease, often associated with diabetes mellitus. Clinical manifestations may include black nasal secretions, fever, lethargy, headache, orbital pain, sudden loss of vision, ophthalmoplegia, proptosis, ptosis, mydriasis, corneal anaesthesia, chemosis, periorbital cellulitis, sinusitis, epistaxis, facial paralysis, loss of sensation in rhinocerebral mucormycosis trigeminal nerve territory and seizures, and the most typical sign of infection is the presence of a necrotic ulcer in the palatal or nasal mucosa.

On the contrary the clinical role of posaconazole as primary treatment has been supported by a number of researchers despite mixed laboratory evidence rhinocerebral mucormycosis its effectiveness Deferasirox and deferiprone are new iron chelators, which in contrast to deferoxamine cannot be utilized by the fungi as siderophores According to rhinocerebral mucormycosis research of Ibrahim et al 20 both deferasirox and deferiprone have been proven to be effective agents against mucormycosis in animal models.

Furthermore deferasirox has also been used successfully as salvage therapy in a case of rhinocerebral mucormycosis opening up new areas of clinical research Reversal of underlying predisposing conditions is of paramount importance.

Euglycemia should be restored rapidly and any immunosuppressive conditions reversed if possible The surgical approach should be based on the clinical state of the patient with timely interventions for appropriate debridement of infected areas Spellberg et al 18 specify the resolution of immunosuppression, radiographical signs and clinical symptomatology as the objectives of treatment rhinocerebral mucormycosis Conclusions Rhinocerebral mucormycosis rhinocerebral mucormycosis remains a poorly understood disease with high mortality rate.

The authors have declared that no competing interests exist. Importance of immediate surgical intervention and rhinocerebral mucormycosis treatment for rhinocerebral mucormycosis.


Epidemiology and outcome of zygomycosis: European Review for Rhinocerebral mucormycosis and Pharmacological Sciences.

Novel perspectives on mucormycosis: The epidemiological features of invasive mycotic infections in the San Francisco Bay area, Hosseini S, Borghei P.


Rhinocerebral mucormycosis and rhino-orbitocerebral mucormycosis. Otolaryngol Head Neck Surg. Survival factors in rhino-orbital-cerebral mucormycosis. Fatal strokes in patients with rhinocerebral mucormycosis mucormycosis and associated vasculopathy.

The day after hospitalization the patient developed a ptosis of the left eye associated with edema of the upper eyelid and the left cheek.

Related Post