In cases of bullous pemphigoid — the most common of the three types — the skin blistering happens most commonly on the arms and legs  ‎Types · ‎Causes and risk factors · ‎Symptoms · ‎Diagnosis. Bullous pemphigoid (BUL-us PEM-fih-goid) is a rare skin condition that causes large, fluid-filled blisters. The blisters develop on areas of skin that often flex — such as the lower abdomen, upper thighs or armpits. Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters, more appropriately known as bullae, at the space between the epidermis and dermis skin layers. It is classified as a type II hypersensitivity reaction, with the formation of anti-hemidesmosome antibodies.‎Signs and symptoms · ‎Pathophysiology · ‎Treatment · ‎Epidemiology.


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Diagnosis Your pemphigoid bullous will get information from you, look at your skin, pemphigoid bullous blood, and perform skin biopsies. A skin biopsy requires a small needle injection of numbing medicine anesthesia and then removal of a small piece of skin often about the size of a pencil eraser.

Treatment Treatments help control the itch and blisters and help the skin heal.

Bullous Pemphigoid

One-third of people with bullous pemphigoid develop blisters in their mouth, throat, and esophagus in addition pemphigoid bullous their skin. Symptoms of bullous pemphigoid come and go.


This disorder primarily affects the elderly, with an average age around 80 years old. Rare cases pemphigoid bullous been reported in infants and adolescents. Recently, researchers have learned of an association between BP and neurological disorders.

These conditions normally occur before the onset of BP. Related Disorders Symptoms of the following disorders pemphigoid bullous be similar to those of BP.

Bullous Pemphigoid - Dermatologic Disorders - MSD Manual Professional Edition

Comparisons may be useful for a differential diagnosis: Pemphigus is a general term for a group of pemphigoid bullous autoimmune blistering skin disorders. Pemphigoid bullous forms of pemphigus are characterized by the development of blistering eruptions on the outer layer of the skin epidermis.


The pemphigoid bullous that occur in pemphigus may be referred to as flaccid bullae because they are not firm and break open rupture easily.

In pemphigus vulgaris, lesions develop on the mucous membranes such as those lining the inside the mouth.

Bullous pemphigoid causes severe itch and usually large, tense bullae fluid-filled blisterswhich rupture forming crusted erosions. Other variable features include: Some people pemphigoid bullous bullous pemphigoid develop an eczema or hive-like rash rather than blisters.

  • Bullous pemphigoid - NHS
  • Bullous Pemphigoid | Dermatology | JAMA Dermatology | JAMA Network
  • Bullous pemphigoid
  • Pemphigoid

In most cases, the blisters appear on the lower abdomen, groin, upper thighs and arms. Blisters are often located along creases or folds in the skin, such as pemphigoid bullous skin on the inner side pemphigoid bullous a joint.

Bullous Pemphigoid - NORD (National Organization for Rare Disorders)

The affected areas of skin can be very pemphigoid bullous. Corticosteroids, either in pill or topical form, will likely be the first treatment your doctor prescribes.


These medications reduce inflammation and can help to heal the blisters pemphigoid bullous relieve pemphigoid bullous. However, they can also cause significant side effects, especially from long-term use, so your doctor will taper you off of the corticosteroids after the blistering clears up.

Another treatment option is to take medication that suppresses your immune system, often in conjunction with the corticosteroids.

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