Visit for more related articles at Research & Reviews: Journal of Botanical Sciences Among nanomaterials, nanoparticles have been supporting to create. A nanoparticle (or nanopowder or nanocluster or nanocrystal) is a microscopic particle with at least one dimension less than nm. Nanoparticle research is currently an area of intense scientific research, due to a wide variety of potential applications in biomedical, optical, and electronic fields. PDF | Nanotechnology refers to the creation and utilization of materials whose constituents exist at the 15+ million members; + million publications; k+ research projects . and physical methods are Biological ways of nanoparticles.


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Anti-HER2 with generic name trastuzumab or trade name herceptin is a humanized monoclonal antibody nanoparticles research articleswhich has been approved by the FDA since for treatment of metastatic breast cancer [ 192024 ]. In this study we conjugated the gold nanoparticles with anti-HER2 antibody trastuzumab through either non-covalent or covalent linkages.

Nanoparticles- The current Research

The trastuzumab-conjugated gold nanoparticles were then used to specifically label breast cancer cells, KPL4 line, for imaging of the cells. As seen from figure 1in the case of the gold nanoparticles without conjugation with trastuzumab, the gold nanoparticles could not find the cancer cells and nothing was observed in the dark-field microscopy image A2.

When the gold nanoparticles were directly conjugated with trastuzumab, the gold nanoparticles nanoparticles research articles on the cancer cells and these cancer cells were clearly observed in the dark-field microscopy image A4 by nanoparticles research articles of the scattering light of the gold nanoparticles.

When the amino-gold nanoparticles amino-GNP were covalently conjugated with trastuzumab through l-ethyl 3-dimethylaminopropyl ethylcarbodiimide EDC connection, the gold nanoparticles concentrated on the cancer cells as well, but these cancer cells were observed with slightly lower intensity in the dark-field microscopy image A6 in comparison with those in the image A4.

However, the gold nanoparticles directly conjugated with trastuzumab were able to be stored in a freezer for only about two weeks before they lost their activity; while the gold nanoparticles covalently conjugated with trastuzumab were stable for storage for about two months.


Standard image High-resolution image Export PowerPoint slide 3. Basal cell carcinoma fingerprinted detection Recently, the surface enhanced Raman scattering SERS has attracted much interest in the field of nanoparticles research articles due to the significant enhance of the labeling signals of molecular vibrations on the surface of metallic nanoparticles.


Nanoparticles research articles Au-antibody solutions were dropped on the surface of the tissue and the SERS signals were collected and analyzed [ 7 ].

Figures 2 A and B show the colored and micro spectroscopy image of the tissue, where the cancer cell area may be the dark colored regions, for example, region A1, A2, B1 and B2. The antigen—antibody coupling oriented the Au-antibody colloids close to the BCC surface.

In comparison, using the principle component analysis method, where the SERS signals were compared with each other, then the difference of the SERS spectra from the average spectrum is mapped in figure 2 C.

In figure 2 Cthe yellow to the red colored areas such as C1 and C2 areas can be considered as cancer regions. From nanoparticles research articles the figures, only A2, B2, C2 and D2 regions can be surely considered as the cancer areas, while A1, B1, C1 and D1 may be assigned as the position of a skin hole where the cell concentration is higher than in other parts.

By principle nanoparticles research articles analysis, only those regions were highlighted which differ from other regions and the non-carcinomas can also be observed.

However, in some special regions, one can make a mistake during the diagnosis. In addition, according to the collecting time of each spectrum being nearly 5 s, the whole SERS map collecting time should be longer than 2 h.

Areas D1 and D2 are the same position on the tissue with A1 and A2, respectively.


In figure D, the difference of D1 and D2 show that only red colored D2 and the nanoparticles research articles color area is the infected area and D1 is not. Antibacterial test using silver nanoparticles The quantitatively antibacterial study of AgNP in Luria—Bertani LB broth is shown in figure 3which presents the dynamics of Escherichia coli E.

Vertical axis represents optical density at nm 1 optical density at nm, OD, equals the concentration of 1.

The initial number of E.

Journal of Nanomedicine & Nanotechnology

For the negative control and the TSC control, E. The concentration of E.

The situation is different with the presence of AgNP because of the well-known antibacterial property of this metal [ 25 ]. Examples include conductive inks, pastes and fillers which utilize silver nanoparticles for their nanoparticles research articles electrical conductivity, stability, and low sintering temperatures.

Silver nanoparticles | List of High Impact Articles | PPts | Journals | Videos

They are utilized as a part of the medicinal division, in buyer items, for building materials, in PC innovation or for waste remediation. By yearly creation volumes and by number of items, silica nanoparticles [38]. Nanoengineering nanoparticles research articles us to grow the surface region of silver particles notably.

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